Description

Fen1 Inhibitor C3 CAS NO 2109805-87-8 is a high-purity, small molecule compound designed as a potent and selective inhibitor of the Fen1 enzyme, a key target in DNA replication and repair pathways. This compound is critical for advanced biochemical research and drug discovery programs focused on oncology and genetic stability. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in developing novel therapeutic agents.

Application

• Biochemical Research: Used as a selective tool compound to study the role and mechanism of the Fen1 nuclease in DNA replication, long-patch base excision repair, and Okazaki fragment processing.
• Oncology Drug Discovery: Serves as a lead compound or reference standard in high-throughput screening and hit-to-lead optimization campaigns targeting cancer cells with DNA repair deficiencies.
• Mechanistic Studies: Enables investigation of synthetic lethality and combination therapies, particularly in cancers with homologous recombination defects (e.g., BRCA mutations).
• Enzyme Kinetics & Profiling: Employed in in vitro assays to determine inhibitory constants (IC50/Ki) and assess selectivity against related nucleases and proteases.
• Cellular Pathway Analysis: Used in cell-based models to validate target engagement, modulate DNA repair pathways, and study downstream phenotypic effects.

Basic Information

Product Name	Fen1 Inhibitor C3
CAS No.	2109805-87-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	FEN1 Inhibitor C3; FEN1 Inhibitor; Flap Endonuclease 1 Inhibitor C3; DNA Replication Inhibitor C3; 2109805-87-8; Fen1 nuclease inhibitor; LP-BER inhibitor; Okazaki fragment maturation inhibitor
EINECS	Contact for details

Quality Control

Our Fen1 Inhibitor C3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.