Description

Chir 99021 Dihydrochloride is a high-purity, small molecule compound primarily utilized as a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3). This compound is critical for research and development in the life sciences, enabling the study of cellular signaling pathways related to metabolism, cell proliferation, and neurobiology. It is an essential tool for pharmaceutical R&D, academic research institutions, and biotechnology companies focused on metabolic disorders, neurodegenerative diseases, and oncology.

Application

• Biochemical Research: A key reagent for studying the Wnt/β-catenin signaling pathway and its role in cellular processes.
• Pharmaceutical Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in drug discovery programs targeting GSK-3.
• Stem Cell Research: Employed to maintain pluripotency and enhance the self-renewal of embryonic stem cells in culture.
• Neurobiology Studies: Investigated for its potential neuroprotective effects and role in tau protein phosphorylation, relevant to Alzheimer's disease research.
• Metabolic Disorder Models: Applied in preclinical research for diabetes and obesity to understand insulin signaling and glucose homeostasis.
• Oncology Research: Used to explore the involvement of GSK-3 inhibition in cancer cell survival and proliferation.

Basic Information

Product Name	Chir 99021 Dihydrochloride
CAS No.	2109414-84-6
Molecular Formula	C₂₂H₂₀Cl₂N₈O
Molecular Weight	483.35 g/mol
Synonyms	CHIR99021 dihydrochloride; CT99021 dihydrochloride; 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile dihydrochloride; 3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-, dihydrochloride; GSK-3 Inhibitor XV; CHIR-99021 2HCl; CT-99021 2HCl; GSK-3β inhibitor CHIR99021 2HCl
EINECS	Contact for details

Quality Control

Our Chir 99021 Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.