Description

Cdk9-In-4D is a potent and selective small molecule inhibitor of cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation. This compound matters for researchers and developers as it provides a critical tool for probing CDK9-dependent pathways in oncology, virology, and inflammatory disease research. It is primarily needed by pharmaceutical R&D teams, academic research laboratories, and biotechnology companies focused on developing novel therapeutics targeting transcriptional dysregulation.

Application

• Biomedical Research: A key chemical probe for studying the role of CDK9 in cell cycle control, apoptosis, and signal transduction pathways.
• Oncology Drug Discovery: Used in in vitro and in vivo studies to validate CDK9 as a therapeutic target for various cancers, including leukemias and solid tumors.
• Virology Studies: Applied in research to investigate host factors like CDK9 involved in viral replication, particularly for HIV and other viruses dependent on transcriptional activation.
• Inflammation & Immunology Research: Utilized to explore the inhibition of CDK9 in modulating inflammatory gene expression and cytokine production.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in assay development and screening campaigns for CDK9 inhibitors.
• Mechanistic Biology: Enables detailed mechanistic studies of transcriptional pause-release and the effects of its inhibition on specific gene subsets.

Basic Information

Product Name	Cdk9-In-4D
CAS No.	2105956-51-0
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	CDK9-IN-4D; Cdk9 Inhibitor 4D; 2105956-51-0; 4-(4-((3-(tert-Butyl)-1-phenyl-1H-pyrazol-5-yl)amino)pyrimidin-2-yl)morpholine; N-(3-(tert-Butyl)-1-phenyl-1H-pyrazol-5-yl)-2-morpholinopyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our Cdk9-In-4D is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to ensure long-term stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.