Description

Ketohexokinase Inhibitor 1 is a potent and selective small molecule inhibitor of the ketohexokinase (KHK) enzyme, a key regulator of fructose metabolism. This compound is of significant interest for research into metabolic disorders, including non-alcoholic fatty liver disease (NAFLD), diabetes, and obesity, by targeting a critical pathway in fructose utilization. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic disease research and preclinical drug discovery programs.

Application

• Metabolic Disease Research: A critical tool for investigating the role of fructose metabolism in the pathogenesis of NAFLD, insulin resistance, and type 2 diabetes.
• Preclinical Drug Discovery: Serves as a reference compound or a starting point for the development of novel therapeutics targeting the KHK pathway.
• Biochemical Assay Development: Used to validate and optimize high-throughput screening assays for identifying new KHK inhibitors.
• Mechanistic Studies: Enables detailed study of fructose-induced metabolic stress, inflammation, and fibrosis in cellular and animal models.
• Academic Research: Supports fundamental research in biochemistry and physiology to elucidate fructose metabolism.

Basic Information

Product Name	Ketohexokinase Inhibitor 1
CAS No.	2102501-84-6
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	KHK Inhibitor 1; Ketohexokinase Inhibitor; 2102501-84-6; PF-06835919; (S)-N-(1-(5-(Cyclopropylcarbamoyl)-2-methoxyphenyl)ethyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide; PF06835919
EINECS	Contact for details

Quality Control

Our Ketohexokinase Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research use. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (Mass Spec)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.