Description

Rad51-In-17 is a potent and selective small-molecule inhibitor of the Rad51 protein, a key mediator of DNA repair via homologous recombination. This compound is of significant interest for its potential to sensitize cancer cells to DNA-damaging therapies by disrupting a critical repair pathway. It is primarily utilized by researchers and pharmaceutical developers in the fields of oncology, molecular biology, and drug discovery for target validation, mechanism-of-action studies, and combination therapy research.

Application

• Oncology Research: Used as a chemical probe to study the role of homologous recombination repair (HRR) in cancer cell survival and resistance to chemotherapy and radiotherapy.
• Drug Discovery: Serves as a lead compound or reference standard in the development of novel Rad51 inhibitors and combination cancer therapies.
• Biochemical Assays: Employed in in vitro enzymatic and cellular assays to measure Rad51 inhibition and its downstream effects on DNA repair.
• Mechanistic Studies: Facilitates research into DNA damage response pathways, synthetic lethality, and the identification of biomarkers for HRR-deficient cancers.
• Academic Research: A valuable tool for universities and research institutes investigating genome stability, DNA repair mechanisms, and cancer biology.

Basic Information

Product Name	Rad51-In-17
CAS No.	2101739-18-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Rad51 Inhibitor-17; Rad51-IN-17; 2101739-18-6; Rad51 protein inhibitor 17; DNA repair inhibitor Rad51-In-17; Homologous recombination inhibitor
EINECS	Contact for details

Quality Control

Our Rad51-In-17 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity assessment by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions to maintain stability and potency. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.