Description

Gsk2894631A CAS NO 2101626-26-8 is a potent and selective small molecule inhibitor of the Wnt/β-catenin signaling pathway, a critical target in oncology and regenerative medicine research. This compound matters for its ability to precisely modulate a key developmental pathway implicated in cancer stem cell maintenance and tissue homeostasis. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for cancers such as colorectal, hepatocellular carcinoma, and other malignancies driven by Wnt pathway dysregulation.

Application

• Oncology Research: Investigation of Wnt/β-catenin signaling in cancer cell proliferation, survival, and metastasis.
• Drug Discovery & Development: Used as a lead compound or reference standard in high-throughput screening and preclinical studies for novel anti-cancer agents.
• Stem Cell Biology: Studying the role of Wnt signaling in stem cell self-renewal, differentiation, and tissue regeneration.
• Biochemical Assays: Serving as a critical tool compound in pathway inhibition studies and mechanism-of-action validation.
• Academic Research: Fundamental research into developmental biology and disease mechanisms associated with the Wnt pathway.
• Biomarker Development: Assisting in the identification and validation of pharmacodynamic biomarkers for Wnt-targeted therapies.

Basic Information

Product Name	Gsk2894631A
CAS No.	2101626-26-8
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	GSK2894631A; GSK-2894631A; 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(5-methylpyrazin-2-yl)quinazolin-4-amine; Wnt Pathway Inhibitor IV; Tankyrase Inhibitor; AXIN Stabilizer
EINECS	Contact for details

Quality Control

Our Gsk2894631A is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.