Description

Protac Brd4-Binding Moiety 1 is a high-purity chemical building block specifically designed for the development of Proteolysis Targeting Chimeras (PROTACs). This compound matters as a critical ligand for the BET protein BRD4, enabling the targeted degradation of disease-relevant proteins, a revolutionary approach in modern drug discovery. It is essential for pharmaceutical researchers, medicinal chemists, and biotechnology companies engaged in the development of novel targeted protein degradation therapies for oncology, inflammatory diseases, and beyond.

Application

• PROTAC Molecule Synthesis: Serves as the key BRD4-targeting warhead in the construction of heterobifunctional PROTAC degraders.
• Drug Discovery Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for BET protein inhibitors and degraders.
• Chemical Biology Probes: Incorporated into molecular tools to study BRD4 biology and its role in transcriptional regulation and disease pathways.
• Oncology R&D: A foundational component for developing novel therapeutics targeting cancers driven by BRD4 dysregulation.
• Academic Research: Utilized in university and institutional labs for fundamental research on epigenetic regulation and targeted protein degradation.
• Preclinical Development: Supports the synthesis of candidate molecules for in vitro and in vivo efficacy and pharmacokinetic studies.

Basic Information

Product Name	Protac Brd4-Binding Moiety 1
CAS No.	2101200-10-4
Molecular Formula	C19H17N5O2S
Molecular Weight	379.44 g/mol
Synonyms	(S)-N-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-methyl-2-(methylsulfonyl)propanamide; BRD4 Ligand for PROTAC; PROTAC BRD4 Ligand 1; BET Bromodomain Inhibitor Fragment; Thienotriazolodiazepine-based BRD4 Binder; (S)-JQ1 derivative; ARV-825 component moiety
EINECS	Contact for details

Quality Control

Our Protac Brd4-Binding Moiety 1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, NMR, and MS for structural confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee reproducible results for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Chiral Purity (HPLC)	≥98% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.