Description

Kdm4D-In-1 CAS NO 2098902-68-0 is a potent and selective small molecule inhibitor of the KDM4D lysine demethylase enzyme, a key epigenetic regulator. This compound is a critical research tool for investigating the role of histone methylation in cellular processes such as gene expression, DNA repair, and cell differentiation. It is essential for academic and pharmaceutical researchers focused on oncology, neurobiology, and the development of novel epigenetic therapies.

Application

• Epigenetics Research: Used as a selective chemical probe to study the biological function and inhibition of the KDM4D (JMJD2D) histone demethylase in various cellular contexts.
• Oncology Studies: Investigated for its potential to modulate gene expression programs in cancer cell lines and animal models, aiding in target validation for cancer therapy.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) campaigns to discover new epigenetic modulators.
• Mechanism of Action Studies: Employed to elucidate the role of specific histone methylation marks (e.g., H3K9me3/2) in transcriptional regulation and chromatin remodeling.
• Stem Cell & Differentiation Research: Applied in studies exploring how epigenetic modifications influence pluripotency, lineage commitment, and cellular reprogramming.
• Neuroscience Research: Utilized to examine the impact of epigenetic dysregulation in neurological disorders and cognitive function.

Basic Information

Product Name	Kdm4D-In-1
CAS No.	2098902-68-0
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	KDM4D-IN-1; KDM4D Inhibitor; JMJD2D Inhibitor; (S)-2-(4-((4-(Dimethylamino)phenyl)amino)quinazolin-2-yl)-N-(1-hydroxy-3-methylbutan-2-yl)acetamide; 2098902-68-0; KDM4D Inhibitor, (S)-Isomer; Histone Demethylase KDM4D Inhibitor
EINECS	Contact for details

Quality Control

Our Kdm4D-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing identity, purity, and strength is provided to ensure the material meets the stringent requirements for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.