Description

Thalidomide-o-Peg4-Propargyl is a bifunctional chemical linker featuring a thalidomide moiety and a propargyl group, connected by a tetraethylene glycol (PEG4) spacer. This compound is specifically engineered for use in PROTAC (Proteolysis Targeting Chimera) research and targeted protein degradation studies, enabling the precise construction of novel therapeutic molecules. It is a critical reagent for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing next-generation cancer therapies and chemical biology tools.

Application

• PROTAC Molecule Synthesis: Serves as a key building block for constructing heterobifunctional degraders that recruit E3 ubiquitin ligases.
• Targeted Protein Degradation (TPD): Used in the development of novel therapeutic agents designed to selectively degrade disease-causing proteins.
• Chemical Biology Probes: Enables the creation of activity-based probes for studying cereblon (CRBN) binding and ubiquitin-proteasome system (UPS) pathways.
• Bioconjugation: The propargyl group allows for efficient, site-specific conjugation via click chemistry (e.g., copper-catalyzed azide-alkyne cycloaddition) with azide-functionalized molecules.
• Drug Discovery Research: Facilitates the exploration of structure-activity relationships (SAR) in oncology and immunology drug candidates.
• Preclinical Development: Supports the synthesis and optimization of linker-drug conjugates for in vitro and in vivo evaluation.

Basic Information

Product Name	Thalidomide-o-Peg4-Propargyl
CAS No.	2098799-77-8
Molecular Formula	C29H35N3O10
Molecular Weight	585.60 g/mol
Synonyms	Thalidomide-PEG4-propargyl; Thalidomide-O1-PEG4-alkyne; 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione; CRBN Ligand-PEG4-Alkyne; (S)-Thalidomide-PEG4-propargyl; E3 Ligase Ligand Linker 10; Propargyl-PEG4-thalidomide
EINECS	Contact for details

Quality Control

Our Thalidomide-o-Peg4-Propargyl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the product should be handled under anhydrous conditions and stored with desiccant to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.