Description

n-(4-Azidobutyl)-2-((2-(2,6-Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Oxy)Acetamide is a sophisticated bifunctional chemical linker designed for advanced bioconjugation and proteolysis-targeting chimera (PROTAC) development. This compound integrates a photoactivatable azide group with a cereblon (CRBN)-binding phthalimide moiety, enabling precise, light-controlled crosslinking and targeted protein degradation studies. It is an essential research-grade reagent for pharmaceutical R&D, chemical biology, and the development of novel targeted protein degradation therapeutics.

Application

• PROTAC (Proteolysis-Targeting Chimera) Synthesis: Serves as a critical linker component connecting E3 ubiquitin ligase ligands (via the dioxopiperidine/phthalimide moiety) to target protein-binding warheads.
• Photoaffinity Labeling Probes: The azide group allows for the creation of probes for mapping protein-ligand interactions and binding sites through UV light-induced crosslinking.
• Chemical Biology Tool Development: Used to create bifunctional molecules for studying cereblon-dependent protein degradation pathways and substrate recruitment.
• Bioconjugation and ADC (Antibody-Drug Conjugate) Research: Facilitates the site-specific attachment of payloads to antibodies or other biomolecules via click chemistry compatible azide functionality.
• Targeted Protein Degradation Platform Development: A key building block for academic and industrial research focused on discovering new molecular glues and degraders.
• Precision Medicine Research: Enables the design of novel therapeutic agents aimed at degrading disease-causing proteins previously considered "undruggable".

Basic Information

Product Name	n-(4-Azidobutyl)-2-((2-(2,6-Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Oxy)Acetamide
CAS No.	2098488-36-7
Molecular Formula	C23H23N5O7
Molecular Weight	481.46 g/mol
Synonyms	4-((2-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl azide; N-(4-Azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide; CRBN Ligand-Linker Conjugate 16; Azide-PEG3-CRBN Ligand; PROTAC Linker for CRBN; Phthalimide Conjugate with Azido-PEG Linker; Cereblon Ligand-Azide Conjugate
EINECS	Contact for details

Quality Control

Our n-(4-Azidobutyl)-2-((2-(2,6-Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Oxy)Acetamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. This compound is light-sensitive and should be handled under appropriate conditions to maintain its chemical integrity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.