Description

Sirt2-Protac-1 is a potent and selective proteolysis-targeting chimera (PROTAC) designed to degrade Sirtuin 2 (SIRT2), a NAD+-dependent deacetylase. This compound matters as a cutting-edge research tool for investigating the role of SIRT2 in cellular processes, offering a mechanism distinct from traditional enzymatic inhibition. It is primarily needed by pharmaceutical researchers and academic institutions focused on oncology, neurodegenerative diseases, and metabolic disorders, where SIRT2 modulation is a promising therapeutic strategy. The compound is supplied as a high-purity material suitable for biochemical and cellular studies.

Application

• Biochemical Research: Used as a selective molecular probe to study SIRT2 biology and validate its role in specific signaling pathways.
• Drug Discovery: Serves as a lead compound or tool molecule in the development of novel targeted protein degradation (TPD) therapies.
• Oncology Research: Applied in in vitro and in vivo studies to explore the therapeutic potential of SIRT2 degradation in various cancer models.
• Neurodegenerative Disease Research: Utilized to investigate the link between SIRT2 activity and pathologies such as Parkinson's and Alzheimer's disease.
• Mechanistic Studies: Enables the study of ubiquitin-proteasome system (UPS) engagement and PROTAC mechanism-of-action (MOA) for SIRT2.
• High-Throughput Screening (HTS): Can be used as a reference standard in assays designed to discover new SIRT2 degraders or related compounds.

Basic Information

Product Name	Sirt2-Protac-1
CAS No.	2098487-75-1
Molecular Formula	C₄₀H₄₈ClN₇O₇S
Molecular Weight	806.37 g/mol
Synonyms	PROTAC SIRT2 Degrader-1; SIRT2-PROTAC; (S)-N-((S)-1-((4-(4-((4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)phenyl)carbamoyl)phenyl)piperazin-1-yl)-3-(4-(4-chlorophenoxy)phenyl)-1-oxopropan-2-yl)-2-((S)-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Sirt2 Degrader; SIRT2 Targeting PROTAC; Sirtuin 2 PROTAC Degrader
EINECS	Contact for details

Quality Control

Our Sirt2-Protac-1 is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and quality specifications. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the rigorous demands of pharmaceutical R&D. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, keep containers sealed under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.