Description

Tyk2-In-2 is a potent and selective small molecule inhibitor of the Tyrosine Kinase 2 (TYK2) enzyme, a key component of the JAK-STAT signaling pathway. This compound is a critical research tool for investigating inflammatory and autoimmune disease mechanisms, offering high specificity to minimize off-target effects. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in immunology, oncology, and drug discovery programs.

Application

• Biochemical Research: Used as a selective probe to study the role of TYK2 in cytokine signaling pathways (e.g., IL-12, IL-23, Type I IFN).
• Drug Discovery & Development: Serves as a reference compound or lead molecule for developing novel therapeutics targeting autoimmune diseases like psoriasis, lupus, and inflammatory bowel disease (IBD).
• Cellular Assays: Employed in in vitro studies to assess the impact of TYK2 inhibition on immune cell function and proliferation.
• Target Validation: Aids in confirming TYK2 as a therapeutic target in various preclinical models of inflammation and cancer.
• High-Throughput Screening (HTS): Can be used as a control or standard in screening campaigns to identify new TYK2 inhibitor scaffolds.

Basic Information

Product Name	Tyk2-In-2
CAS No.	2098466-94-3
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	Tyk2-IN-2; TYK2 Inhibitor 2; 1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one; BMS-986165 analogue; Deucravacitinib analogue; TYK2 JH2 inhibitor
EINECS	Contact for details

Quality Control

Our Tyk2-In-2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our rigorous specifications for research-grade compounds.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.