Description

Chk1 Inhibitor CAS NO 2097938-64-0 is a potent and selective small molecule inhibitor targeting the Checkpoint kinase 1 (Chk1) protein, a key regulator in the DNA damage response pathway. This compound is essential for advanced research in oncology and cell biology, enabling the study of cell cycle arrest, DNA repair mechanisms, and sensitization to genotoxic agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel cancer therapeutics and understanding cellular stress responses.

Application

• Oncology Research: Used as a critical tool compound to investigate the role of Chk1 in DNA damage checkpoint signaling and its potential as a therapeutic target in various cancers.
• Chemo- and Radio-Sensitization Studies: Employed to study the enhancement of cancer cell death when combined with DNA-damaging chemotherapy drugs or radiation therapy.
• Cell Cycle Analysis: Facilitates research into cell cycle progression, G2/M checkpoint abrogation, and mitotic catastrophe in experimental models.
• Preclinical Drug Development: Serves as a reference standard or lead compound in the discovery and optimization of novel Chk1 inhibitor drug candidates.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro kinase assays to evaluate potency and selectivity against Chk1 and related kinases.
• Synergistic Combination Therapy Research: Investigated in combination with PARP inhibitors, ATR inhibitors, or other targeted agents to overcome therapeutic resistance.

Basic Information

Product Name	Chk1 Inhibitor CAS NO 2097938-64-0
CAS No.	2097938-64-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Chk1 Inhibitor; Checkpoint Kinase 1 Inhibitor; CHK1 Inhibitor; (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide; SAR-020106; CAS 2097938-64-0; Prexasertib analog; DNA Damage Response Inhibitor
EINECS	Contact for details

Quality Control

Our Chk1 Inhibitor is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We support research compliance with full traceability and stability data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize exposure to atmospheric moisture. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.