Description

Protac Brd9-Binding Moiety 1 Hydrochloride is a high-purity chemical building block designed for the development of Proteolysis Targeting Chimeras (PROTACs). This compound serves as a critical ligand that specifically binds to the bromodomain-containing protein 9 (BRD9), enabling the targeted degradation of proteins of interest. It is essential for researchers and pharmaceutical developers in the fields of chemical biology, oncology, and targeted protein degradation. The material is supplied as a hydrochloride salt to enhance stability and solubility for experimental use.

Application

• PROTAC Molecule Synthesis: A key component for constructing heterobifunctional PROTAC degraders targeting BRD9.
• Chemical Biology Research: Used in studies investigating bromodomain function, chromatin remodeling, and epigenetic regulation.
• Drug Discovery & Preclinical Development: Serves as a starting material for developing novel therapeutic candidates in oncology and other disease areas.
• Biochemical Assay Development: Utilized as a reference standard or competitor in binding assays (e.g., SPR, FP) to study BRD9-ligand interactions.
• Structure-Activity Relationship (SAR) Studies: Provides a core scaffold for medicinal chemistry optimization to improve potency and selectivity.

Basic Information

Product Name	Protac Brd9-Binding Moiety 1 Hydrochloride
CAS No.	2097512-23-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	BRD9 Ligand 1 HCl; BRD9-Binding Moiety for PROTACs; PROTAC BRD9 Ligand HCl; (S)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate Hydrochloride (IUPAC-based); BRD9 Inhibitor Fragment; BRD9-Targeting Warhead; Degrader Building Block for BRD9
EINECS	Contact for details

Quality Control

Our Protac Brd9-Binding Moiety 1 Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.