Description

(S)-3'-Amino Blebbistatin is a potent and selective chemical probe and research-grade inhibitor of non-muscle myosin II (NMMII) ATPase activity. This compound matters for researchers investigating fundamental cellular processes such as cytokinesis, cell motility, and morphological changes, offering superior enantiomeric purity for precise mechanistic studies. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on cytoskeletal dynamics, cardiovascular disease, and oncology target validation.

Application

• Biochemical Research: Selective inhibition of non-muscle myosin II ATPase activity in in vitro enzyme assays.
• Cell Biology Studies: Investigation of cytokinesis, cell adhesion, migration, and morphological changes in various cell lines.
• Pharmaceutical Development: A key tool compound for target validation in pathways involving myosin II, such as in cancer metastasis and cardiovascular disorders.
• Mechanistic Probes: Used to study the role of myosin II in neuronal growth cone dynamics and synaptic plasticity.
• High-Content Screening (HCS): Utilized as a reference standard in phenotypic screening assays for drug discovery.
• Chemical Biology: Serves as a scaffold for developing more potent or selective derivatives and activity-based probes.

Basic Information

Product Name	(S)-3'-Amino Blebbistatin
CAS No.	2097141-18-7
Molecular Formula	C18H16N4O2
Molecular Weight	320.35 g/mol
Synonyms	(S)-3'-Aminoblebbistatin; (S)-3'-Amino-blebbistatin; (S)-3'-NH2-Blebbistatin; (S)-3'-Amino-1,2,3,4-tetrahydro-1-(4-hydroxy-5-iodophenyl)-6-phenyl-4a,8a-diazanaphthalene-7,8-dione; (S)-enantiomer of 3'-Aminoblebbistatin; 3'-Aminoblebbistatin (S-isomer); Myosin II Inhibitor (S)-3'-Amino
EINECS	Contact for details

Quality Control

Our (S)-3'-Amino Blebbistatin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.