Description

(S)-3'-Hydroxy Blebbistatin is a potent and selective small-molecule inhibitor of non-muscle myosin II (NMMII) ATPase activity. This compound is a key research-grade chemical tool for investigating cytoskeletal dynamics, cell motility, and cell division processes. It is primarily utilized by researchers in the fields of cell biology, pharmacology, and drug discovery for in vitro studies.

Application

• Biochemical Research: A critical tool for studying the specific functions of non-muscle myosin II isoforms in cellular processes.
• Cell Biology Studies: Used to inhibit myosin II-dependent contractility to investigate cell adhesion, migration, cytokinesis, and morphological changes.
• Pharmacology & Drug Discovery: Serves as a reference standard and a lead compound for developing novel therapeutics targeting myosin II in conditions like cancer and cardiovascular diseases.
• Signal Transduction Research: Employed to dissect signaling pathways that regulate the actin-myosin cytoskeleton.
• Academic & Institutional Research: Essential for university and pharmaceutical R&D laboratories conducting fundamental life science research.

Basic Information

Product Name	(S)-3'-Hydroxy Blebbistatin
CAS No.	2097136-42-8
Molecular Formula	C18H16N2O4
Molecular Weight	324.33 g/mol
Synonyms	(S)-3'-Hydroxyblebbistatin; (S)-3'-OH-Blebbistatin; (-)-3'-Hydroxyblebbistatin; (S)-enantiomer of 3'-Hydroxyblebbistatin; 3'-Hydroxyblebbistatin (S-isomer); Myosin II Inhibitor (S)-3'-Hydroxy; 1-Phenyl-1,2-dihydro-4-(3-hydroxy-[1,1'-biphenyl]-4-yl)-6-methyl-2-oxopyridine-3-carbonitrile (S-form)
EINECS	Contact for details

Quality Control

Our (S)-3'-Hydroxy Blebbistatin is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including HPLC chromatograms and NMR spectra. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.