Description

2,3-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical advanced pharmaceutical intermediate and cross-coupling reagent in modern organic synthesis. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for introducing the 2,3-difluoropyridin-4-yl moiety into target molecules, enabling the synthesis of novel drug candidates and functional materials.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Serves as a precursor for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Used in the synthesis of organic electronic materials, such as those for OLEDs and semiconductors.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the development of molecular probes for diagnostic applications.

Basic Information

Product Name	2,3-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	2096996-99-3
Molecular Formula	C11H14BF2NO2
Molecular Weight	241.04 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-difluoropyridine; 2,3-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2,3-Difluoropyridine-4-boronic acid pinacol ester; 2,3-Difluoro-4-pyridinylboronic acid pinacol ester; 4-(Pinacolboryl)-2,3-difluoropyridine; 2,3-Difluoro-4-(pinacolatoboryl)pyridine
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.