Description

6-Chloro-5-Trifluoromethylpyridine-3-Boronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through versatile cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyridine-containing drug candidates, particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require the specific trifluoromethylpyridine scaffold for enhanced bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs) with tailored electronic or catalytic properties.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and heterobiaryl bonds, a fundamental transformation in medicinal and process chemistry.
• Chemical Library Development: Utilized in high-throughput and parallel synthesis for generating diverse compound libraries for biological screening and structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates at various scales, from research to pilot plant.

Basic Information

Product Name	6-Chloro-5-Trifluoromethylpyridine-3-Boronic Acid
CAS No.	2096336-32-0
Molecular Formula	C6H4BClF3NO2
Molecular Weight	225.36 g/mol
Synonyms	(6-Chloro-5-(trifluoromethyl)pyridin-3-yl)boronic acid; 3-Borono-6-chloro-5-(trifluoromethyl)pyridine; 6-Chloro-5-(trifluoromethyl)-3-pyridineboronic acid; 6-Chloro-5-trifluoromethylpyridine-3-boronic acid pinacol ester (protected form); 5-Trifluoromethyl-6-chloropyridine-3-boronic acid; Boronic acid, B-[6-chloro-5-(trifluoromethyl)-3-pyridinyl]-; CAS 2096336-32-0
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Trifluoromethylpyridine-3-Boronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and cGMP (current Good Manufacturing Practice) environments where reliable material performance is non-negotiable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.