Description

Csf1R-In-1 is a potent and selective small molecule inhibitor of the Colony Stimulating Factor 1 Receptor (CSF1R), a key target in immuno-oncology and inflammatory disease research. This compound matters for its role in modulating macrophage and microglia activity, offering a critical tool for investigating tumor microenvironments and neurodegenerative pathways. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for cancer, autoimmune disorders, and CNS diseases.

Application

• Immuno-oncology Research: Investigation of tumor-associated macrophages (TAMs) and their role in cancer progression and immunotherapy resistance.
• Inflammatory Disease Models: Study of CSF1R signaling in rheumatoid arthritis, multiple sclerosis, and other autoimmune conditions.
• Neurodegenerative Disease Research: Exploration of microglial function in Alzheimer's disease, Parkinson's disease, and ALS.
• Preclinical Drug Development: Serving as a reference compound or positive control in high-throughput screening and lead optimization campaigns.
• Cell Biology Studies: In vitro and in vivo modulation of monocyte differentiation and macrophage proliferation.
• Biomarker Discovery: Aiding in the identification of pharmacodynamic markers for CSF1R-targeted therapies.

Basic Information

Product Name	Csf1R-In-1
CAS No.	2095849-04-8
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	CSF1R Inhibitor 1; CSF1R-IN-1; BLZ945 analog; Colony Stimulating Factor 1 Receptor Inhibitor 1; (S)-N-(5-Chloro-1H-benzo[d]imidazol-2-yl)-1-(4-(4-methylpiperazin-1-yl)phenyl)ethyl)-1H-imidazole-4-carboxamide; 2095849-04-8; CSF1Ri-1
EINECS	Contact for details

Quality Control

Our Csf1R-In-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.