Description

Eif4A3-In-2 is a potent and selective small molecule inhibitor of the eukaryotic initiation factor 4A3 (eIF4A3), a key component of the exon junction complex. This compound matters for its role in modulating RNA biology and its potential as a research tool for investigating post-transcriptional gene regulation and RNA metabolism. Researchers in academic institutions, pharmaceutical R&D, and biotechnology companies focused on oncology, neurology, and rare genetic diseases will find this inhibitor valuable for probing novel therapeutic pathways.

Application

• Biochemical Research: Used as a selective tool compound to study the function of eIF4A3 and its role in nonsense-mediated mRNA decay (NMD).
• Oncology Research: Investigated for its potential to disrupt oncogenic translation programs and inhibit cancer cell proliferation in preclinical models.
• Neurological Disease Studies: Applied in research exploring the link between RNA processing defects and neurodegenerative conditions.
• Mechanistic Biology: Employed to dissect the molecular mechanisms of the exon junction complex and its impact on mRNA localization and stability.
• High-Throughput Screening: Serves as a reference standard or positive control in assays designed to discover novel eIF4A3 modulators.
• Pharmacology & Target Validation: Utilized in proof-of-concept studies to validate eIF4A3 as a therapeutic target for various diseases.

Basic Information

Product Name	Eif4A3-In-2
CAS No.	2095677-20-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	eIF4A3 Inhibitor 2; EIF4A3-IN-2; eIF4A3-In-2; 2095677-20-4; Eukaryotic Initiation Factor 4A3 Inhibitor 2; Exon Junction Complex Inhibitor; RNA Helicase Inhibitor
EINECS	Contact for details

Quality Control

Our Eif4A3-In-2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and analytical results is provided with every shipment to support your research reproducibility and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.