Description

Rip1 Kinase Inhibitor 1 is a potent and selective small molecule inhibitor targeting the Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). This compound matters significantly for researchers as it provides a critical tool for elucidating the role of RIPK1 in regulating cell death pathways, including necroptosis and apoptosis, and its involvement in inflammatory and degenerative diseases. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for conditions like inflammatory bowel disease, Alzheimer's, ALS, and ischemic injury.

Application

• Mechanistic research into RIPK1-mediated necroptosis and apoptosis signaling pathways.
• Pre-clinical in vitro and in vivo studies for inflammatory and neurodegenerative diseases.
• High-throughput screening (HTS) campaigns to discover and validate new drug candidates.
• Tool compound for studying the interplay between inflammation and cell death in cancer models.
• Investigating potential therapeutic applications in autoimmune disorders and tissue injury.
• Use as a reference standard in bioanalytical method development for pharmacokinetic studies.

Basic Information

Product Name	Rip1 Kinase Inhibitor 1
CAS No.	2095515-38-9
Molecular Formula	C₂₃H₂₅ClN₆O₂
Molecular Weight	452.94 g/mol
Synonyms	RIPK1 Inhibitor; RIP1 Inhibitor; GSK'547; GSK547; GSK-547; 7-Oxo-7H-benzo[e]perimidine-4-carboxamide derivative; (S)-N-(3-Chloro-4-fluorophenyl)-1-(2,4-dimethoxybenzyl)-6-methoxy-7-oxo-6,7-dihydro-1H-benzo[e]perimidine-4-carboxamide
EINECS	Contact for details

Quality Control

Our Rip1 Kinase Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under desiccated conditions. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption. The compound is intended for research use in a laboratory setting only.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.