Description

Eif4A3 Inhibitor 53A is a potent and selective small-molecule inhibitor of the eukaryotic initiation factor 4A-III (eIF4A3), a key component of the exon junction complex (EJC). This compound matters for researchers investigating post-transcriptional gene regulation, nonsense-mediated mRNA decay (NMD), and RNA biology. It is primarily needed by pharmaceutical R&D teams and academic laboratories focused on oncology, genetic disorders, and the development of novel therapeutic strategies targeting RNA-protein interactions.

Application

• Biochemical Research: A critical tool for in vitro studies to dissect the mechanistic role of eIF4A3 and the EJC in mRNA metabolism and quality control pathways.
• Cell-Based Assays: Used to inhibit eIF4A3 function in cell culture to study its impact on gene expression, splicing, and NMD efficiency.
• Target Validation: Employed in preclinical research to validate eIF4A3 as a potential therapeutic target in cancers where its activity is dysregulated.
• Mechanistic Probes: Serves as a chemical probe to understand the link between RNA surveillance mechanisms and disease states, including neurodevelopmental disorders and certain malignancies.
• High-Throughput Screening (HTS): Can be used as a reference compound or positive control in HTS campaigns aimed at discovering novel eIF4A3 modulators.

Basic Information

Product Name	Eif4A3 Inhibitor 53A
CAS No.	2095486-67-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	eIF4A3 Inhibitor 53A; 53A, Eif4A3 Inhibitor; EIF4A3 Inhibitor, 53A; Exon Junction Complex Inhibitor 53A; eIF4A-III Inhibitor; Compound 53A; NMD Inhibitor (context-dependent); Research Compound 2095486-67-0
EINECS	Contact for details

Quality Control

Our Eif4A3 Inhibitor 53A is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all quality parameters are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep containers in a freezer.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.