Description

E3 Ligase Ligand 12 is a high-purity, synthetic small molecule specifically designed for use in targeted protein degradation research and PROTAC (Proteolysis Targeting Chimera) development. This compound serves as a critical chemical tool for recruiting the cellular ubiquitin-proteasome system to degrade disease-relevant proteins. It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on advancing novel therapeutic modalities in oncology, neurodegenerative diseases, and beyond.

Application

• PROTAC Molecule Synthesis: A key component for constructing heterobifunctional degraders that link target proteins to E3 ubiquitin ligases.
• Chemical Biology Research: Used to study and validate novel E3 ligase targets and mechanisms of ubiquitination.
• Drug Discovery Platforms: Integral to screening and optimizing targeted protein degradation candidates in preclinical development.
• Academic & Institutional Research: Enables fundamental studies on protein homeostasis, cellular signaling pathways, and disease mechanisms.
• Biopharmaceutical Development: Supports the creation of next-generation therapeutics with potential advantages over traditional small molecule inhibitors.

Basic Information

Product Name	E3 Ligase Ligand 12
CAS No.	2095244-42-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	E3 Ligand 12; VHL Ligand 12; VH032 derivative; (1S,2R,4R)-4-((4-((S)-2-Amino-3-methylbutanamido)benzyl)carbamoyl)-2-(2,6-dioxopiperidin-3-yl)cyclopentane-1-carboxylic acid; Cereblon E3 Ligase Ligand; PROTAC Linker Ligand; Molecular Glue Precursor; Targeted Protein Degradation Tool Compound
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of E3 Ligase Ligand 12 is characterized using advanced analytical techniques to guarantee identity, purity, and stability. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, LC-MS) and spectroscopic profiles (NMR) are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.