Description

4-((2-(2-(2-(2-Aminoethoxy)Ethoxy)Ethoxy)Ethyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel therapeutic agents. This compound is critical for researchers and manufacturers developing targeted protein degradation (TPD) platforms, such as Proteolysis-Targeting Chimeras (PROTACs). It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CDMOs (Contract Development and Manufacturing Organizations) focused on next-generation oncology and disease-modifying therapies.

Application

• PROTAC (Proteolysis-Targeting Chimera) Linker Synthesis: Serves as a key bifunctional component connecting E3 ligase ligands to target protein binders.
• Molecular Glue Development: Used in the research and development of small molecules that induce protein-protein interactions for targeted degradation.
• Bioconjugation: The terminal amino group and PEG-like chain enable conjugation to antibodies, peptides, or other targeting moieties for advanced drug delivery systems.
• Preclinical & Clinical Candidate Synthesis: A vital building block in the production of investigational new drugs (INDs) for oncology, neurodegenerative, and inflammatory diseases.
• Chemical Biology Research: Employed as a tool compound to study ubiquitin-proteasome system (UPS) pathways and intracellular protein turnover.
• High-Value Intermediate Supply: Supplied to CDMOs and pharmaceutical companies for scale-up under cGMP conditions for clinical and commercial manufacturing.

Basic Information

Product Name	4-((2-(2-(2-(2-Aminoethoxy)Ethoxy)Ethoxy)Ethyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione
CAS No.	2093416-31-8
Molecular Formula	C23H31N5O8
Molecular Weight	505.52 g/mol
Synonyms	PROTAC Linker 1; Thalidomide-PEG4-amine; Lenalidomide-PEG4-NH2; 2-(2,6-Dioxo-3-piperidyl)-4-[[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]amino]isoindole-1,3-dione; 4-((2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; E3 Ligase Ligand-PEG4-Amine; Cereblon Ligand-PEG4-NH2; IMD-PEG4-NH2
EINECS	Contact for details

Quality Control

Our production of 4-((2-(2-(2-(2-Aminoethoxy)Ethoxy)Ethoxy)Ethyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical research and development. The material is characterized and released against comprehensive specifications, including identity confirmation by NMR and mass spectrometry, and purity assessment by HPLC. Certificates of Analysis (COA) detailing all critical quality attributes are provided with every shipment. We support development from milligram to kilogram scale under quality-controlled environments suitable for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially light-sensitive nature. For long-term storage, desiccants are recommended. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.