Description

E3 Ligand-Linker Conjugate 5 is a sophisticated bifunctional chemical entity designed for targeted protein degradation research. This compound is integral to the development of Proteolysis Targeting Chimeras (PROTACs), a revolutionary therapeutic modality. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology, neurodegenerative diseases, and targeted drug discovery. The conjugate enables the precise hijacking of cellular degradation machinery to eliminate disease-causing proteins.

Application

• PROTAC Molecule Synthesis: Serves as a critical building block for constructing novel PROTAC degraders targeting specific proteins of interest.
• Chemical Biology Research: Used in studies to understand E3 ligase engagement, linker optimization, and structure-activity relationships (SAR) in targeted degradation.
• Drug Discovery Platforms: A key reagent in high-throughput screening and library synthesis for identifying lead degradation compounds.
• Oncology & Immunology R&D: Applied in the development of novel therapeutics aimed at degrading oncoproteins or immune-modulatory proteins.
• Academic Research: Utilized in university and institutional labs for fundamental research on the ubiquitin-proteasome system and protein homeostasis.
• Bioconjugation & Probe Development: Can be used to create activity-based probes for studying E3 ligase function and localization within cells.

Basic Information

Item	Details
Product Name	E3 Ligand-Linker Conjugate 5
CAS No.	2093388-69-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	E3 Ligand-Linker Conjugate 5; PROTAC Linker Conjugate; E3 Ubiquitin Ligase Ligand-Linker; Bifunctional Degradation Compound; Targeted Protein Degradation Reagent; E3 Ligand-Connector 5; Chemical Degrader Intermediate; Heterobifunctional Molecule 5
EINECS	Contact for details

Quality Control

Our E3 Ligand-Linker Conjugate 5 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, which is critical for sensitive biological assays. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and other relevant specifications is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and must be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.