Description

Protac 11 is a potent and selective small molecule degrader, specifically a proteolysis-targeting chimera (PROTAC), designed for targeted protein degradation research. This compound is a critical tool for investigating novel therapeutic strategies by inducing the ubiquitin-proteasome system to degrade specific proteins of interest. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology, neurodegenerative diseases, and targeted drug discovery. The high-purity material is essential for reliable and reproducible results in complex biological assays.

Application

• Targeted Protein Degradation (TPD) Research: A foundational tool for proof-of-concept studies in PROTAC technology and ubiquitin-proteasome system (UPS) biology.
• Drug Discovery & Preclinical Development: Used in hit-to-lead optimization and mechanism-of-action studies for novel degrader molecules.
• Oncology Research: Employed to degrade specific oncogenic proteins and study tumor cell proliferation, survival, and signaling pathways.
• Chemical Biology & Proteomics: Serves as a molecular probe to study protein function, protein-protein interactions, and cellular signaling networks.
• Academic & Institutional Research: Fundamental research into disease mechanisms where selective protein knockdown is required, beyond the capabilities of traditional inhibitors.
• Biotech & Pharma R&D: Critical for internal pipeline development of next-generation therapeutic modalities based on protein degradation.

Basic Information

Product Name	Protac 11
CAS No.	2093386-22-0
Molecular Formula	C31H34F3N5O5S
Molecular Weight	645.69 g/mol
Synonyms	PROTAC11; ARV-771; (S,R,S)-AHPC-PEG4-VHL Ligand 2; BET Degrader PROTAC; ARV-771 PROTAC; VHL-based BET Degrader; dBET6; BMS-986399
EINECS	Contact for details

Quality Control

Our Protac 11 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals, ensuring material integrity for sensitive biological assays. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.