Description

Benzene, 1-Bromo-2-(Bromomethyl)-5-Fluoro-4-Methyl- is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique substitution pattern enables precise structural modifications. Industrial and academic researchers in fine chemical, pharmaceutical R&D, and material science need this specialized intermediate to synthesize novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides, fungicides, and insecticides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Material Science Research: Used in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and halogen functional groups.
• Cross-Coupling Reactions: The bromine substituents make it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings for constructing complex biaryl systems.
• Fluorine Chemistry Studies: Acts as a model compound in methodological development for introducing and transforming fluorinated aromatic systems.
• Chemical Library Development: Employed in combinatorial and parallel synthesis for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Benzene, 1-Bromo-2-(Bromomethyl)-5-Fluoro-4-Methyl-
CAS No.	2090850-25-0
Molecular Formula	C8H7Br2F
Molecular Weight	281.95 g/mol
Synonyms	1-Bromo-2-(bromomethyl)-5-fluoro-4-methylbenzene; 2-(Bromomethyl)-1-bromo-5-fluoro-4-methylbenzene; 4-Methyl-5-fluoro-1,2-bis(bromomethyl)benzene; 5-Fluoro-4-methyl-1,2-bis(bromomethyl)benzene; 1,2-Bis(bromomethyl)-4-fluoro-5-methylbenzene; 2,3-Bis(bromomethyl)-6-fluorotoluene; 6-Fluoro-2,3-bis(bromomethyl)toluene; (Bromomethyl)(5-fluoro-4-methyl-2-bromophenyl)methane
EINECS	Contact for details

Quality Control

Our Benzene, 1-Bromo-2-(Bromomethyl)-5-Fluoro-4-Methyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single impurity	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.