Description

5-(Difluoromethoxy)-6-Methylpyridin-2-Amine CAS NO 2089378-17-4 is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethoxy-substituted pyridine core. This compound is of significant commercial importance as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing next-generation small-molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, especially in kinase inhibitor and antiviral therapeutic programs.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the commercial-scale synthesis of approved pharmaceuticals requiring this specific molecular fragment.
• Ligand and Catalyst Development: Potential use in designing novel ligands for catalysis or metal-organic frameworks due to its nitrogen-containing heterocyclic structure.

Basic Information

Product Name	5-(Difluoromethoxy)-6-Methylpyridin-2-Amine
CAS No.	2089378-17-4
Molecular Formula	C8H9F2N2O
Molecular Weight	187.17 g/mol
Synonyms	6-Methyl-5-(difluoromethoxy)pyridin-2-amine; 2-Amino-5-(difluoromethoxy)-6-methylpyridine; 5-(Difluoromethoxy)-6-methyl-2-pyridinamine; 2089378-17-4; 6-Methyl-5-(difluoromethoxy)-2-aminopyridine; 2-Pyridinamine, 5-(difluoromethoxy)-6-methyl-
EINECS	Contact for details

Quality Control

Every batch of 5-(Difluoromethoxy)-6-Methylpyridin-2-Amine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the stringent requirements for pharmaceutical-grade intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.