Description

Pim Inhibitor 1 (Phosphate) is a potent and selective small molecule inhibitor targeting the Pim kinase family, a key regulator of cell survival and proliferation. This compound is crucial for advancing research in oncology and hematology, providing a valuable tool for studying signaling pathways involved in cancer progression. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutic agents for cancers such as leukemia, lymphoma, and solid tumors.

Application

• Oncology Research: A key biochemical tool for investigating the role of Pim kinases in tumor cell survival, growth, and resistance to apoptosis.
• Drug Discovery & Development: Serves as a reference standard and lead compound in high-throughput screening and structure-activity relationship (SAR) studies for novel kinase inhibitors.
• Hematological Malignancy Studies: Used in preclinical models to evaluate therapeutic efficacy against leukemia, multiple myeloma, and lymphomas.
• Signal Transduction Pathway Analysis: Enables the dissection of downstream effects of Pim kinase inhibition on critical pathways like JAK/STAT and PI3K/Akt/mTOR.
• Combination Therapy Research: Investigated for potential synergistic effects when used alongside other chemotherapeutic agents or targeted therapies.
• Biomarker Development: Aids in identifying and validating pharmacodynamic biomarkers for Pim kinase activity in cellular and animal models.

Basic Information

Product Name	Pim Inhibitor 1 (Phosphate)
CAS No.	2088852-47-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PIM1 Inhibitor 1 phosphate; Pim-1 Kinase Inhibitor 1 (phosphate salt); (S)-5-(5-((4-(2,3-Dihydroxypropoxy)phenyl)amino)-1,3,4-thiadiazol-2-yl)-3-methylimidazolidine-2,4-dione phosphate; PIM Inhibitor I, phosphate; PIM-1 Inhibitor (phosphate); Research Compound 2088852-47-3
EINECS	Contact for details

Quality Control

Our Pim Inhibitor 1 (Phosphate) is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.