Description

3-Formyl-5-((Trimethylsilyl)Ethynyl)Benzenesulfonyl Fluoride is a high-purity, multi-functional chemical building block designed for advanced synthetic chemistry. This compound is valued for its unique combination of a reactive sulfonyl fluoride group, an aldehyde, and a protected alkyne, enabling its use in click chemistry and covalent inhibitor development. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel bioactive molecules and chemical probes.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing covalent inhibitors targeting serine hydrolases and other enzymes.
• Chemical Biology Probe Development: Used in activity-based protein profiling (ABPP) to label and study enzyme function in complex biological systems.
• Sulfur(VI) Fluoride Exchange (SuFEx) Chemistry: The sulfonyl fluoride moiety serves as a reliable handle for SuFEx click reactions, enabling robust bioconjugation and polymer synthesis.
• Agrochemical Research: Intermediate in the development of new herbicides and pesticides with novel modes of action.
• Material Science: Precursor for creating functionalized surfaces and advanced polymers with specific chemical reactivity.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	3-Formyl-5-((Trimethylsilyl)Ethynyl)Benzenesulfonyl Fluoride (≥95%)
CAS No.	2088829-13-2
Molecular Formula	C₁₂H₁₃FO₃SSi
Molecular Weight	284.38 g/mol
Synonyms	5-((Trimethylsilyl)ethynyl)-3-formylbenzenesulfonyl fluoride; 3-Formyl-5-((trimethylsilyl)ethynyl)benzene-1-sulfonyl fluoride; 5-(Trimethylsilylethynyl)isophthalaldehyde sulfonyl fluoride; TMS-Ethynyl Benzaldehyde Sulfonyl Fluoride; Sulfonyl Fluoride Click Chemistry Reagent; Covalent Probe Building Block; SuFEx Reagent Intermediate
EINECS	Contact for details

Quality Control

Our 3-Formyl-5-((Trimethylsilyl)Ethynyl)Benzenesulfonyl Fluoride is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.