Description

3-(Bromomethyl)-5-((Trimethylsilyl)ethynyl)benzenesulfonyl fluoride is a high-purity, multi-functional chemical building block designed for advanced synthetic applications. This compound is valued for its unique combination of a reactive benzenesulfonyl fluoride (BSF) warhead, a bromomethyl handle, and a protected alkyne group, enabling precise and modular construction of complex molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, chemical biology, and materials science.

Application

• Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry: The sulfonyl fluoride moiety serves as a key electrophile for constructing sulfonate and sulfonamide linkages under mild, aqueous conditions.
• Proteolysis-Targeting Chimeras (PROTACs) & Molecular Glues: Used as a versatile linker component for conjugating E3 ligase ligands to target protein binders, facilitating targeted protein degradation.
• Covalent Inhibitor Development: Enables the synthesis of small-molecule probes and drug candidates that form irreversible bonds with specific amino acid residues (e.g., tyrosine, lysine, histidine) in target proteins.
• Chemical Biology Probes: Acts as a scaffold for creating activity-based probes (ABPs) to label, identify, and study enzymes and other proteins in complex biological systems.
• Polymer & Materials Science: Serves as a monomer or cross-linking agent for synthesizing functional polymers with tailored properties via post-polymerization modification.
• Intermediate for Agrochemicals: Used in the synthesis of novel herbicides, fungicides, and insecticides that leverage sulfonyl fluoride chemistry for enhanced bioactivity and stability.

Basic Information

Product Name	3-(Bromomethyl)-5-((Trimethylsilyl)ethynyl)benzenesulfonyl fluoride
CAS No.	2088829-12-1
Molecular Formula	C13H16BrFO2SSi
Molecular Weight	363.30 g/mol
Synonyms	3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride; 5-((Trimethylsilyl)ethynyl)-3-(bromomethyl)benzenesulfonyl fluoride; Benzenesulfonyl fluoride, 3-(bromomethyl)-5-[(trimethylsilyl)ethynyl]-; 3-(Bromomethyl)-5-(2-trimethylsilylethynyl)benzenesulfonyl fluoride; TMS-Ethynyl-Bromomethyl-Benzenesulfonyl Fluoride; BSF-Bromomethyl-TMS-Alkyne building block
EINECS	Contact for details

Quality Control

Our 3-(Bromomethyl)-5-((Trimethylsilyl)ethynyl)benzenesulfonyl fluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.