Description

Rorγt Inhibitor 1 CAS NO 2079892-79-6 is a potent and selective small molecule inhibitor targeting the Retinoic acid receptor-related orphan receptor gamma t (RORγt), a key transcription factor for the differentiation and function of Th17 cells. This compound is a critical research tool for investigating autoimmune and inflammatory disease pathways, offering high specificity to minimize off-target effects. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on immunology, drug discovery, and preclinical studies for conditions like psoriasis, multiple sclerosis, and inflammatory bowel disease.

Application

• Immunology Research: Fundamental tool for studying Th17 cell biology, cytokine production (IL-17, IL-22), and the RORγt signaling pathway.
• Autoimmune Disease Models: Used in preclinical in vitro and in vivo studies to validate RORγt as a therapeutic target for diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis.
• Drug Discovery & Screening: Serves as a reference standard or positive control in high-throughput screening (HTS) assays to identify and characterize novel RORγt modulators.
• Inflammatory Pathway Analysis: Enables mechanistic studies in cellular assays to dissect the role of RORγt in various inflammatory cascades and immune cell differentiation.
• Biomarker Development: Supports research into pharmacodynamic biomarkers related to RORγt inhibition for clinical translation.
• Chemical Biology & Proteomics: Can be used in pull-down assays or as a molecular probe to study protein-protein interactions and downstream effects of RORγt inhibition.

Basic Information

Product Name	Rorγt Inhibitor 1
CAS No.	2079892-79-6
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	RORγt Inhibitor 1; ROR gamma t Inhibitor 1; (S)-2-(4-(4-Fluorophenyl)-2-methyl-5,6-dihydrobenzo[h]quinazolin-7(8H)-yl)-N-(5-methylpyridin-2-yl)acetamide; GSK-805; GSK805; GSK 805; 2079892-79-6; RORC Inhibitor
EINECS	Contact for details

Quality Control

Our Rorγt Inhibitor 1 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) providing full characterization data, including purity by HPLC, identity confirmation (NMR, MS), and impurity profile. We adhere to high-purity research-grade standards, and specifications can be tailored to meet specific project requirements. COAs are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.