Description

Wehi-539 Hcl is a potent and selective small-molecule inhibitor of Bcl-2 family proteins, specifically targeting Bcl-xL. This compound is a critical research tool for studying apoptotic pathways and has significant implications in the development of novel oncology therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cancer biology and drug discovery.

Application

• Biomedical Research: A key reagent for investigating the role of Bcl-xL in programmed cell death (apoptosis) and cellular survival mechanisms.
• Oncology Drug Discovery: Used in high-throughput screening and target validation studies for developing next-generation anti-cancer agents.
• Mechanistic Studies: Essential for elucidating the structure-activity relationship (SAR) of Bcl-2 protein family inhibitors.
• Preclinical Development: Employed in in vitro and in vivo models to assess the efficacy and therapeutic potential of targeting Bcl-xL.
• Chemical Biology: Serves as a precise molecular probe to dissect complex signaling networks involving apoptosis regulation.
• Synergy Studies: Used to evaluate combination therapies with other chemotherapeutic agents or targeted drugs.

Basic Information

Product Name	Wehi-539 Hcl
CAS No.	2070018-33-4
Molecular Formula	C30H34ClN5O3 • HCl
Molecular Weight	584.54 g/mol
Synonyms	WEHI-539 hydrochloride; WEHI539; 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R,2S,3R,4R)-3-(hydroxymethyl)-4-(methoxycarbonylamino)cyclopentyl]oxy]phenyl]carbamoyl]-1H-pyrazole-3-carboxamide hydrochloride; Bcl-xL inhibitor WEHI-539; Apoptosis inducer WEHI-539
EINECS	Contact for details

Quality Control

Our Wehi-539 Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and NMR/LC-MS for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.