Description

(S)-4-(tert-Butyl)-2-(5-Fluoropyridin-2-Yl)-4,5-Dihydrooxazole is a high-purity, chiral oxazoline derivative of significant importance in modern synthetic chemistry and pharmaceutical development. Its core value lies in its role as a versatile and effective ligand or chiral auxiliary for asymmetric catalysis, enabling the synthesis of enantiomerically pure compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control in their synthetic routes.

Application

• As a chiral ligand in asymmetric metal-catalyzed reactions, such as hydrogenation, cyclopropanation, and Diels-Alder reactions.
• As a chiral auxiliary for the diastereoselective synthesis of complex organic molecules and active pharmaceutical ingredients (APIs).
• In the research and development of novel therapeutic agents, particularly where specific enantiomeric purity is critical for biological activity.
• For the synthesis of advanced intermediates in agrochemicals and specialty chemicals requiring defined stereochemistry.
• In methodological development within academic and industrial research laboratories exploring new catalytic systems.
• For process chemistry optimization in scaling up the production of chiral drugs.

Basic Information

Product Name	(S)-4-(tert-Butyl)-2-(5-Fluoropyridin-2-Yl)-4,5-Dihydrooxazole
CAS No.	2068819-66-7
Molecular Formula	C12H15FN2O
Molecular Weight	222.26 g/mol
Synonyms	(S)-4-tert-Butyl-2-(5-fluoropyridin-2-yl)-4,5-dihydrooxazole; (S)-2-(5-Fluoropyridin-2-yl)-4-(tert-butyl)-4,5-dihydrooxazole; (S)-4-(tert-Butyl)-2-(5-fluoro-2-pyridyl)-2-oxazoline; (S)-t-Bu-PyFox; (S)-4-(1,1-Dimethylethyl)-2-(5-fluoro-2-pyridinyl)-4,5-dihydrooxazole; (S)-5-Fluoro-2-(4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine; Chiral Oxazoline Ligand
EINECS	Contact for details

Quality Control

Our (S)-4-(tert-Butyl)-2-(5-Fluoropyridin-2-Yl)-4,5-Dihydrooxazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.