Description

E3 Ligase Ligand-Linker Conjugates 7 is a high-purity, synthetic chemical compound designed for advanced proteolysis-targeting chimera (PROTAC) research and development. This specialized molecule serves as a critical bifunctional component, linking an E3 ubiquitin ligase ligand to a target protein-binding warhead to facilitate the targeted degradation of disease-relevant proteins. It is an essential research tool for pharmaceutical scientists and medicinal chemists working in oncology, neurodegenerative diseases, and other therapeutic areas exploring targeted protein degradation (TPD) strategies. The compound enables the creation of novel therapeutic modalities by hijacking the cell's natural protein recycling machinery.

Application

• PROTAC Molecule Synthesis: Core building block for the design and synthesis of proteolysis-targeting chimeras (PROTACs).
• Targeted Protein Degradation (TPD) Research: Facilitates the study of protein function and validation of novel drug targets through induced degradation.
• Chemical Biology Tool Development: Used to create molecular probes for investigating ubiquitin-proteasome system (UPS) pathways and protein-protein interactions.
• Oncology Drug Discovery: Enables the development of degraders targeting oncoproteins traditionally considered "undruggable."
• Neurological Disease Research: Applied in the exploration of degrading pathogenic proteins implicated in conditions like Alzheimer's and Parkinson's disease.
• Biopharmaceutical Development: Serves as a key intermediate in the preclinical development of next-generation therapeutic agents.
• Academic & Industrial R&D: Critical reagent for universities, research institutes, and biotech/pharma companies advancing TPD platforms.

Basic Information

Item	Details
Product Name	E3 Ligase Ligand-Linker Conjugates 7
CAS No.	2064292-52-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate 7; E3 Ligase Ligand-Linker 7; Targeted Protein Degradation Conjugate; TPD Building Block 7; Bifunctional PROTAC Component; Ubiquitin Ligase Recruiter-Linker; Degrader Conjugate Intermediate; (S,R,S)-AHPC-C5-O-C5-NH2 hydrochloride
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 7 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, identity, and other critical parameters. Our quality commitment supports compliance with the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the sealed vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.