Description

Tbk1/Ikkε-In-1 CAS NO 2058264-32-5 is a potent and selective small molecule inhibitor targeting the TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε) signaling pathways. This compound is a critical research tool for elucidating the role of these kinases in cellular processes such as innate immunity, inflammation, and oncogenesis. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and biologists in drug discovery programs focused on autoimmune diseases, viral infections, and cancer therapeutics.

Application

• Biochemical Research: Used as a selective probe to study TBK1 and IKKε kinase activity and signaling cascades in vitro.
• Cell-Based Assays: Applied in cellular models to investigate the role of TBK1/IKKε in inflammatory responses, interferon production, and cell survival pathways.
• Drug Discovery & Development: Serves as a reference compound or starting point for the development of novel therapeutics targeting inflammatory and autoimmune disorders.
• Oncology Research: Employed in studies exploring the involvement of TBK1/IKKε in cancer cell proliferation, survival, and resistance mechanisms.
• Virology Studies: Utilized to dissect host-pathogen interactions, particularly in research concerning viral evasion of innate immune sensing.
• Target Validation: A key tool for validating TBK1 and IKKε as pharmacological targets in various disease models.

Basic Information

Product Name	Tbk1/Ikkε-In-1
CAS No.	2058264-32-5
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	TBK1/IKKε-IN-1; TBK1-IKKε-IN-1; 6-(4-(4-Methylpiperazin-1-yl)phenyl)-N-(pyridin-4-yl)imidazo[1,2-a]pyrazin-8-amine; Amlexanox derivative (TBK1/IKKε inhibitor); IKKε/TBK1 inhibitor; BX795 analog; CAS 2058264-32-5
EINECS	Contact for details

Quality Control

Our Tbk1/Ikkε-In-1 is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (IC50)	Reported value provided (TBK1/IKKε)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.