Description

Grk2-In-1 is a potent and selective small molecule inhibitor targeting the G protein-coupled receptor kinase 2 (GRK2). This compound is a critical research tool for investigating cellular signaling pathways, particularly those involving G protein-coupled receptors (GPCRs) and their role in various physiological and pathological processes. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on cardiovascular diseases, heart failure, and metabolic disorders. The product is supplied as a high-purity biochemical for reliable and reproducible experimental results.

Application

• Biochemical Research: Used as a selective probe to study GRK2-mediated phosphorylation and desensitization of GPCRs in vitro.
• Cardiovascular Disease Models: Applied in cellular and animal studies to investigate the role of GRK2 in heart failure, cardiac hypertrophy, and hypertension.
• Drug Discovery & Development: Serves as a reference compound and pharmacological tool in high-throughput screening (HTS) and lead optimization for novel GRK2 inhibitors.
• Signal Transduction Studies: Facilitates the exploration of β-adrenergic receptor signaling and its cross-talk with other pathways in metabolic regulation.
• Academic & Institutional Research: A key reagent for universities and research institutes conducting fundamental research in molecular pharmacology and cell biology.

Basic Information

Product Name	Grk2-In-1
CAS No.	2055990-90-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	GRK2-IN-1; Grk2-In-1; G protein-coupled receptor kinase 2 inhibitor 1; (Chemical name to be confirmed); Potential research code: CC-401 (example, verify with supplier); GRK2 Inhibitor
EINECS	Contact for details

Quality Control

Our Grk2-In-1 is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectral analysis (NMR, MS) for structural confirmation, to ensure identity, potency, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment upon request, supporting your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.