Description

Tbk1 Protac 1 CAS NO 2052306-13-3 is a high-purity, small-molecule PROTAC (PROteolysis TArgeting Chimera) designed for targeted protein degradation research. This compound is a critical tool for advancing novel therapeutic strategies in oncology and other disease areas by enabling the selective removal of disease-causing proteins. It is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on pioneering targeted protein degradation platforms and drug discovery.

Application

• Targeted Protein Degradation Research: Serves as a key chemical probe for studying PROTAC-mediated ubiquitination and proteasomal degradation of specific target proteins.
• Oncology Drug Discovery: Used in preclinical studies to validate novel targets and develop next-generation cancer therapeutics.
• Mechanistic Biology Studies: Enables investigation of protein function, signaling pathways, and cellular responses through induced protein knockdown.
• High-Throughput Screening (HTS): Acts as a reference compound or positive control in assays designed to discover new PROTAC molecules or E3 ligase binders.
• Chemical Biology Tool: Utilized to explore ternary complex formation, kinetics of degradation, and selectivity profiles in cellular models.
• Academic & Institutional Research: Supports fundamental research in biochemistry, molecular biology, and medicinal chemistry related to the ubiquitin-proteasome system.

Basic Information

Product Name	Tbk1 Protac 1
CAS No.	2052306-13-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Tbk1 PROTAC 1; Tbk1-Protac-1; PROTAC Tbk1 degrader 1; (S,R,S)-AHPC-based Tbk1 PROTAC; BMS-1166-based PROTAC; Cereblon-based Tbk1 degrader; Tbk1-targeting PROTAC; Tbk1 protein degrader
EINECS	Contact for details

Quality Control

Our Tbk1 Protac 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation by NMR and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. For long-term storage under inert atmosphere, seal under argon or nitrogen. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.