Description

p-Gp Inhibitor 1 is a potent and selective small molecule inhibitor of P-glycoprotein (P-gp), a key efflux transporter associated with multidrug resistance. This compound is crucial for pharmaceutical research, particularly in enhancing the bioavailability and efficacy of co-administered therapeutic agents by overcoming transporter-mediated efflux. It is an essential research tool for scientists in drug discovery and development, preclinical pharmacokinetics, and oncology research, where modulating drug transport is critical.

Application

• Drug Discovery & Development: Used as a pharmacological tool to study P-gp-mediated drug efflux and to enhance the intestinal absorption and brain penetration of lead compounds.
• Multidrug Resistance (MDR) Research: Investigated in oncology research to potentially reverse P-gp-associated resistance to chemotherapeutic agents in cancer cell lines and animal models.
• Preclinical ADME Studies: Employed in pharmacokinetic and bioavailability studies to assess the role of P-gp in drug disposition, metabolism, and excretion.
• Blood-Brain Barrier (BBB) Permeation Assays: Applied in neuroscience and CNS drug development to evaluate and improve the brain delivery of candidate drugs.
• In Vitro Transporter Assays: Serves as a reference inhibitor in Caco-2, MDCK-MDR1, and other cell-based assays to characterize substrate-inhibitor relationships for P-gp.
• Formulation Science: Aids in the development of formulations aimed at improving the solubility and permeability of poorly bioavailable drugs.

Basic Information

Product Name	p-Gp Inhibitor 1
CAS No.	2050747-49-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	P-glycoprotein Inhibitor 1; P-gp Inhibitor 1; (S)-N-(3,4-Difluorophenyl)-1-(2-oxo-2-((3S,5aR,10bS)-3-propyl-1,2,3,5,5a,6,10,10b-octahydrobenzo[f]pyrrolo[1,2-a]azepin-8-yl)ethyl)pyrrolidine-2-carboxamide; PGP Inhibitor 1; Multidrug Resistance Inhibitor 1
EINECS	Contact for details

Quality Control

Our p-Gp Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to warm to room temperature before opening to minimize moisture condensation. The compound is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/LC-MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.