Description

Plx3397 Hcl is a high-purity, small molecule inhibitor targeting specific kinase pathways. This compound is critical for research and development in oncology and immunology, offering a precise tool for modulating cellular signaling. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in drug discovery and preclinical studies.

Application

• Pharmaceutical Research: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel oncology therapeutics.
• Preclinical Studies: Used in in vitro and in vivo models to investigate the efficacy and mechanism of action of CSF-1R inhibition.
• Biochemical Assays: Employed as a selective inhibitor in high-throughput screening and enzymatic assays to study kinase function and signaling pathways.
• Academic Research: Facilitates fundamental research in tumor microenvironment, macrophage biology, and immune-oncology.
• Process Development: Acts as a critical raw material for process chemistry and scale-up activities in API manufacturing.

Basic Information

Product Name	Plx3397 Hcl
CAS No.	2040295-03-0
Molecular Formula	C₂₁H₂₂ClF₃N₄O₂ • HCl
Molecular Weight	491.79 g/mol
Synonyms	PLX3397 hydrochloride; Pexidartinib hydrochloride; (5-((5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N,2,6-trimethyl-N-(1-methylpiperidin-4-yl)pyrimidin-4-amine hydrochloride); CSF-1R Inhibitor; PLX 3397 HCl; PLX-3397 hydrochloride; Pexidartinib HCl; AC1L1TZK
EINECS	Contact for details

Quality Control

Our Plx3397 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure compliance with research-grade and cGMP standards for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.