Description

E3 Ligand-Linker Conjugate 7 is a specialized bifunctional chemical compound designed for the development of Proteolysis Targeting Chimeras (PROTACs) and other targeted protein degradation technologies. This conjugate integrates a high-affinity ligand for an E3 ubiquitin ligase with a versatile chemical linker, enabling the precise recruitment of target proteins for ubiquitination and subsequent proteasomal degradation. It is an essential research-grade building block for pharmaceutical R&D, chemical biology, and the discovery of novel therapeutic modalities targeting previously "undruggable" proteins.

Application

• PROTAC Molecule Synthesis: Serves as a critical precursor for constructing heterobifunctional PROTAC degraders by conjugating with target protein ligands.
• Chemical Biology Research: Used in studies exploring ubiquitin-proteasome system (UPS) pathways and targeted protein degradation mechanisms.
• Drug Discovery Platforms: Integral to high-throughput screening and library synthesis for identifying novel protein degraders in oncology, neurodegenerative diseases, and inflammatory disorders.
• Bioconjugation & ADC Development: The reactive linker moiety can be utilized for antibody-drug conjugate (ADC) development and other bioconjugation strategies.
• E3 Ligase Profiling: Employed as a tool compound to study the selectivity and activity of specific E3 ligases in cellular environments.

Basic Information

Product Name	E3 Ligand-Linker Conjugate 7
CAS No.	2022182-59-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate 7; E3 Ligand-Linker 7; Targeted Protein Degradation Conjugate 7; Bifunctional Degrader Building Block 7; E3 Ubiquitin Ligase Recruiter 7; (S,R,S)-AHPC-PEG3-C2-NH2 hydrochloride (common core structure type); Linker-E3 Ligand Conjugate; Protein Degradation Tool Compound 7
EINECS	Contact for details

Quality Control

Our E3 Ligand-Linker Conjugate 7 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and MS and NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and other critical specifications is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep containers sealed under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.