Description

E3 Ligand-Linker Conjugate 6 is a specialized PROTAC (PROteolysis TArgeting Chimera) intermediate designed for the development of targeted protein degradation therapeutics. This compound integrates a ligand for an E3 ubiquitin ligase with a chemical linker, serving as a critical building block for creating novel bifunctional molecules. It is essential for pharmaceutical R&D teams and academic researchers focused on oncology, neurodegenerative diseases, and other areas where degrading disease-causing proteins offers a promising therapeutic strategy. The product, identified by CAS number 2022182-57-4, is supplied to the highest purity standards to ensure reliable and reproducible results in complex synthetic pathways.

Application

• PROTAC Molecule Synthesis: A key precursor for constructing bifunctional degraders that link target protein ligands to E3 ligase recruiters.
• Drug Discovery Research: Used in medicinal chemistry for screening and optimizing novel targeted protein degradation (TPD) candidates.
• Chemical Biology Tool Development: Enables the study of protein function and validation of new E3 ligases for degradation applications.
• Oncology Therapeutic Development: Facilitates the creation of degraders aimed at oncoproteins considered "undruggable" by traditional inhibition.
• Academic & Institutional Research: Supports fundamental research in ubiquitin-proteasome system (UPS) pathways and cellular protein homeostasis.
• Biopharmaceutical Process Development: Serves as a reference standard or intermediate in scaling up degrader synthesis for preclinical studies.

Basic Information

Product Name	E3 Ligand-Linker Conjugate 6
CAS No.	2022182-57-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate 6; E3 Ligand-Linker 6; Targeted Protein Degradation Intermediate 6; TPD Conjugate 6; Bifunctional Molecule Precursor 6; Ubiquitin Ligase Recruiter-Linker; Degrader Building Block 6; (Chemical structure-based IUPAC name available upon request)
EINECS	Contact for details

Quality Control

Every batch of E3 Ligand-Linker Conjugate 6 is produced and analyzed under strict quality management protocols to ensure it meets the exacting requirements of pharmaceutical research. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.