Description

Cdk12 Inhibitor E9 S-Isomer CAS NO 2020052-55-3 is a highly selective, small-molecule inhibitor targeting the Cyclin-Dependent Kinase 12 (CDK12) enzyme, specifically the S-enantiomer of the E9 compound. This specificity is critical for advanced pharmaceutical research, enabling precise investigation of CDK12's role in transcription regulation and DNA damage response pathways without off-target effects. It is an essential research-grade chemical for oncology and molecular biology laboratories, academic institutions, and pharmaceutical R&D departments focused on developing novel cancer therapeutics.

Application

• Biochemical Research: Used as a potent and selective tool compound to study the specific biological functions and inhibition mechanisms of CDK12 in cellular models.
• Oncology Drug Discovery: Serves as a key reference standard and lead compound in high-throughput screening and structure-activity relationship (SAR) studies for developing new anti-cancer agents.
• Mechanistic Studies: Enables investigation into the role of CDK12 in transcription elongation, DNA repair (particularly homologous recombination), and its implications in cancers like ovarian and prostate cancer.
• Preclinical Development: Utilized in in vitro and in vivo studies to evaluate pharmacokinetics, pharmacodynamics, and efficacy profiles of CDK12-targeting therapies.
• Chemical Biology: Acts as a molecular probe to dissect kinase signaling networks and identify synthetic lethal interactions for combination therapy strategies.

Basic Information

Product Name	Cdk12 Inhibitor E9 S-Isomer
CAS No.	2020052-55-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CDK12 Inhibitor E9 (S-form); (S)-CDK12 Inhibitor E9; S-Enantiomer of E9; CDK12i E9 S-Isomer; CAS 2020052-55-3; CDK12 Inhibitor; E9 S-Configuration; Kinase Inhibitor E9 (S)
EINECS	Contact for details

Quality Control

Our Cdk12 Inhibitor E9 S-Isomer is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by comprehensive analytical data, including chiral purity verification by HPLC. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation and potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-Isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.