Description

Chlorhexidine-D8 Hcl CAS NO 2012598-75-1 is a deuterated analog of the widely used antiseptic agent chlorhexidine dihydrochloride, where eight hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for enhancing the precision and reliability of analytical methods, particularly in pharmacokinetic and metabolic studies. It is an essential reference standard and tracer for research and quality control laboratories in the pharmaceutical, biotechnology, and analytical chemistry sectors.

Application

• Internal Standard for Quantitative Analysis: Used as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of chlorhexidine and its metabolites in biological matrices.
• Metabolic Pathway Tracing: Enables detailed investigation of drug metabolism, absorption, distribution, and excretion (ADME) studies due to its isotopic signature.
• Pharmaceutical R&D: Serves as a critical tool in the development and validation of analytical methods for new drug formulations containing chlorhexidine.
• Quality Control & Assurance: Employed in GMP/GLP environments to ensure the accuracy and consistency of assay results for chlorhexidine-based products.
• Biomedical Research: Facilitates advanced research in microbiology and dermatology where precise tracking of the antiseptic agent is required.
• Regulatory Submissions: Supports data packages for regulatory authorities (e.g., FDA, EMA) by providing definitive proof of method specificity and accuracy.

Basic Information

Product Name	Chlorhexidine-D8 Hcl
CAS No.	2012598-75-1
Molecular Formula	C22H22D8Cl2N10•2HCl
Molecular Weight	578.40 g/mol (for deuterated form)
Synonyms	Chlorhexidine-d8 dihydrochloride; 1,1'-Hexamethylenebis[5-(p-chlorophenyl)-D8-biguanide] dihydrochloride; Deuterated Chlorhexidine HCl; N,N''''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide-d8 dihydrochloride; Chlorhexidine D8; Chlorhexidine (phenyl-D8) dihydrochloride; Biguanide-d8, chlorhexidine derivative
EINECS	Contact for details

Quality Control

Every batch of Chlorhexidine-D8 Hcl is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail isotopic purity, chemical purity, and confirm identity and strength. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments, supporting compliance with GMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.