Description

C18 Ceramide-D3 (D18:1/18:0-D3) is a deuterium-labeled analog of the naturally occurring sphingolipid, C18 Ceramide, specifically designed for use as an internal standard in quantitative mass spectrometry. This high-purity, isotopically labeled compound is essential for ensuring analytical accuracy and reproducibility in lipidomic research. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and advanced life science sectors for precise quantification of ceramide species in complex biological matrices.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the accurate quantification of endogenous C18 ceramide levels in lipidomics and metabolomics studies.
• Biomedical Research: Used in studies investigating the role of ceramides in cellular signaling, apoptosis, skin barrier function, and metabolic disorders such as diabetes and obesity.
• Drug Discovery & Development: Enables pharmacokinetic (PK) and pharmacodynamic (PD) studies by tracking ceramide metabolism and the efficacy of therapeutic agents targeting sphingolipid pathways.
• Diagnostic Assay Development: Employed in the development and validation of clinical diagnostic tests that measure ceramide levels as biomarkers for cardiovascular disease risk or other health conditions.
• Cosmeceutical & Dermatological Research: Applied in research focused on skin health, aging, and the formulation of products aimed at restoring the skin's lipid barrier.

Basic Information

Product Name	C18 Ceramide-D3 (D18:1/18:0-D3)
CAS No.	2011762-82-4
Molecular Formula	C36H68D3NO3
Molecular Weight	~566.0 g/mol
Synonyms	N-[(1S,3R)-1-[(2S,3R)-2-[(1E,3R)-3-Hydroxy-1-octadecen-1-yl]-3-hydroxyoxolan-2-yl]-3-hydroxy-2,2-bis(hydroxymethyl)propyl]octadecanamide-d3; N-Stearoyl-D-erythro-sphingosine-d3; C18 Ceramide (d18:1/18:0)-d3; Deuterated C18 Ceramide; N-(Octadecanoyl-d3)-sphing-4-enine; (2S,3S,4R)-2-Octadecanamido-1,3,4-octadecanetriol-d3; Cer(d18:1/18:0)-d3
EINECS	Contact for details

Quality Control

Our C18 Ceramide-D3 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is characterized using advanced techniques including NMR and mass spectrometry to confirm structure and isotopic purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and solvent content is provided with every shipment to support your research and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium)	≥ 98 atom % D
Chemical Purity (TLC)	Single spot
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.