Description

6-(Difluoromethyl)Pyridin-3-Ol Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethyl-substituted pyridine core. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modulation. It is primarily sought by research institutions and manufacturers in the global pharmaceutical and agrochemical sectors for developing next-generation small-molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in oncology, neurology, and anti-infective research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the difluoromethyl group enhances biological activity and metabolic stability.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.
• Material Science Precursor: Potential use in creating specialized ligands or functional molecules for advanced materials and catalysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	6-(Difluoromethyl)Pyridin-3-Ol Hydrochloride
CAS No.	2007915-85-5
Molecular Formula	C7H6F2NO•HCl
Molecular Weight	193.58 (Free base) / 230.04 (HCl salt)
Synonyms	3-Hydroxy-6-(difluoromethyl)pyridine hydrochloride; 6-(Difluoromethyl)-3-pyridinol hydrochloride; 6-(Difluoromethyl)-3-hydroxypyridine HCl; 3-Pyridinol, 6-(difluoromethyl)-, hydrochloride; 2007915-85-5; 6-Difluoromethyl-pyridin-3-ol HCl; 5-Hydroxy-2-(difluoromethyl)pyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethyl)Pyridin-3-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A comprehensive Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your project specifications. We support development and commercial projects with material suitable for research use through to cGMP-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.