Description

n-Acetyl-D3-5-Hydroxytryptamine is a deuterated analog of melatonin, a critical biochemical used in advanced research and development. This compound is essential for applications requiring high isotopic purity and metabolic stability, such as internal standards for mass spectrometry. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and manufacturers of diagnostic reagents focused on neurological and sleep-related studies.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering reference standard for the precise quantification of melatonin and related metabolites in complex biological matrices.
• Pharmaceutical Research: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of new therapeutic agents targeting circadian rhythms.
• Diagnostic Assay Development: A key component in calibrating immunoassays and developing high-sensitivity clinical tests for hormonal and neurological biomarkers.
• Isotopic Tracer Studies: Enables detailed metabolic pathway analysis in preclinical research due to its deuterium labeling, providing insights without significant biological interference.
• Reference Material: Provides a certified, high-purity standard for quality control laboratories to validate analytical methods and ensure instrument accuracy.
• Neuroscience & Chronobiology Research: Supports fundamental research into sleep disorders, circadian clock mechanisms, and the role of melatonin in various physiological processes.

Basic Information

Product Name	n-Acetyl-D3-5-Hydroxytryptamine
CAS No.	2001098-07-1
Molecular Formula	C₁₃H₁₃D₃N₂O₂
Molecular Weight	235.28 g/mol
Synonyms	Deuterated Melatonin; Melatonin-d3; N-Acetyl-5-methoxytryptamine-d3; 5-Methoxy-N-acetyltryptamine-d3; [D3]-Melatonin; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide-d3; Circadin-d3; MT-d3
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-D3-5-Hydroxytryptamine is manufactured under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles, verified by advanced analytical techniques including NMR and HPLC-MS. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.