Description

8-Fluoro-7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One is a high-purity fluorinated and methoxylated tetralone derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorine and methoxy motifs into target structures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug discovery programs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or precursor for synthesizing specialized polymers and organic electronic materials with tailored properties.
• Chemical Biology Probes: Employed in the creation of fluorinated molecular probes and tags for studying biological mechanisms and enzyme interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	8-Fluoro-7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One
CAS No.	295779-88-3
Molecular Formula	C₁₁H₁₁FO₂
Molecular Weight	194.20 g/mol
Synonyms	8-Fluoro-7-methoxy-3,4-dihydro-1(2H)-naphthalenone; 8-Fluoro-7-methoxy-1-tetralone; 1(2H)-Naphthalenone, 8-fluoro-7-methoxy-3,4-dihydro-; 8-Fluoro-7-methoxy-3,4-dihydro-2H-naphthalen-1-one; 295779-88-3; 8-Fluoro-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-one; 7-Methoxy-8-fluoro-1-tetralone
EINECS	Contact for details

Quality Control

Our 8-Fluoro-7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.