Description

2-Methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-sulfonyl chloride is a high-purity sulfonyl chloride derivative, a crucial synthetic intermediate in advanced organic chemistry. Its primary value lies in its high reactivity, serving as a key electrophilic building block for constructing complex molecules with sulfonamide or sulfonate linkages. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the benzo[1,4]oxazine core's bioactivity.
• Agrochemical Synthesis: Used to develop new herbicides, fungicides, and insecticides by introducing sulfonamide groups into lead structures to modify activity and selectivity.
• Material Science Research: Employed in the creation of specialty polymers and advanced materials where the sulfonyl chloride group enables covalent attachment to other monomers or surfaces.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation, labeling proteins, or creating activity-based probes for enzyme studies.
• Dye & Pigment Manufacturing: Serves as an intermediate in the production of specialized sulfonated dyes and colorants with enhanced properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D.

Basic Information

Product Name	2-Methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-sulfonyl chloride
CAS No.	293741-60-3
Molecular Formula	C9H8ClNO4S
Molecular Weight	261.68 g/mol
Synonyms	2-Methyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazine-6-sulfonyl chloride; 2H-1,4-Benzoxazine-6-sulfonyl chloride, 3,4-dihydro-2-methyl-3-oxo-; 2-Methyl-3-oxo-4H-benzo[1,4]oxazine-6-sulfonyl chloride; 6-(Chlorosulfonyl)-2-methyl-4H-3,1-benzoxazin-4-one; Benzo[1,4]oxazine-6-sulfonyl chloride, 2-methyl-3-oxo-3,4-dihydro-2H-; 293741-60-3; 2-Methyl-3-oxo-2H-benzo[1,4]oxazine-6-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-sulfonyl chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.