Description

4-(2-Methyl-1,3-Oxazol-5-Yl)Benzenesulfonyl Chloride is a high-value sulfonyl chloride derivative featuring a methyloxazole heterocycle, serving as a critical building block in modern synthetic chemistry. This compound is essential for introducing the sulfonamide pharmacophore, a key structural motif known for imparting biological activity and enhancing molecular properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including potential kinase inhibitors, enzyme modulators, and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the sulfonamide group contributes to efficacy and selectivity.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation, activity-based protein profiling (ABPP), and the development of chemical probes.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	4-(2-Methyl-1,3-Oxazol-5-Yl)Benzenesulfonyl Chloride
CAS No.	293306-72-6
Molecular Formula	C10H8ClNO3S
Molecular Weight	257.69 g/mol
Synonyms	5-(4-Chlorosulfonylphenyl)-2-methyloxazole; 2-Methyl-5-(4-sulfonylchloridophenyl)oxazole; 4-(2-Methyloxazol-5-yl)benzenesulfonyl chloride; Benzenesulfonyl chloride, 4-(2-methyl-5-oxazolyl)-; 293306-72-6; 4-(2-Methyl-1,3-oxazol-5-yl)phenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-(2-Methyl-1,3-Oxazol-5-Yl)Benzenesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.